Absorption of ipsapirone along the human gastrointestinal tract.
نویسندگان
چکیده
Isapirone-HCl (5 mg) was administered orally, rectally and locally, by a remote control drug delivery device (HF-capsule) into different segments of the gastrointestinal tract, to four young healthy male adults. The relative systemic bioavailability of the drug from the colon and rectum was 2-3-fold greater than that from the upper gastrointestinal tract. This supports a rationale for a prolonged-release formulation.
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عنوان ژورنال:
- British journal of clinical pharmacology
دوره 38 1 شماره
صفحات -
تاریخ انتشار 1994